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Nature provides various substances that are able to stimulate the immune system. This mostly concerns structures that are recognised by our immune system as quasi-excitation.

Beta-1.3-1.6-glucans as essential constituents of the cell walls of mushrooms, some plants and bacteria are those pathogen-associated structures. Without being a pathogen, they trigger an immune activation but do not cause disease symptoms.

This means that beta-glucans are a safe, natural and useful food supplement for training the immune system.

Beta-1,3-1,6 glucans act on the cell of the innate immune system

Beta-glucans are recognised through special receptors (Dectin-1 and others) and then internalised by macrophages. These cells are able to break up the beta-glucans and present the constituents on their surface. Therefore the macrophages activate the formation of other cells of the immune system in the lymphatic tissue. These immune cells can then protect the body against new pathogens.

Phagocytes accept beta-glucans better the smaller they are (read more on this in the chapter new formula) and a sufficient supply of beta glucan particles should be available. That is to say, many small particles are better than a few large particles.

APUXAN is the world's only product with beta-glucans having a particle size of smaller than 400 nm. In addition, a daily dosage of APUXAN provides up to 2 trillion beta glucan particles. This allows the particles of APUXAN be absorbed by many phagocytes, leading to a subsequent efficient immune response, demonstrated in a clinical trial.